Since the Lisbon Strategy Report of the European Commission in 2001, there is an intense effort combined with series of targeted policies all over Europe for the stimulation of SMEs for IT and e-business. A lot of initiatives have been implemented in all European countries with various levels of success. In some countries, successful regional policy measures in the field have contributed to the faster improvement of SMEs’ access to the Information Society, whereas, in other regions, especially from the  “new” European countries, the IT and e-business penetration seems to find obstacles in its growth.